NUI Galway scientists have published some very promising findings using adult stem cells for the treatment of diabetic wounds. Dr Aonghus O’Loughlin who completed an MMI Clinician Scientist Fellowship at NUI Galway in 2011 is lead author on the research paper recently published in Diabetes the official journal of the American Diabetes Association.1
Pre-clinical research carried out by Dr O’Loughlin and his collaborator Professor Timothy O’Brien at the Regenerative Medicine Institute (REMEDI) at NUI Galway has shown that a particular type of stem cell known as the mesenchymal stem cell (MSC) increases wound healing when topically administered in a collagen scaffold. Diabetic patients have an impaired ability to heal wounds and there is a critical need to develop new treatments to improve healing particularly in patients with foot ulcers.
The researchers now intend to apply for approval to carry out first-in-human studies of this therapeutic approach and it is hoped that the first clinical trial involving 15 patients will happen in 2014.
Dr Aonghus O’Loughlin speaking at the MMI Annual Scientific Meeting on 14 March 2013.
For more information see the NUI Galway website here.
1Aonghus O’Loughlin Mangesh Kulkarni Michael Creane Erin Vaughan Emma Mooney Georgina Shaw Mary Murphy Peter Dockery Abhay Pandit Timothy O’Brien.Topical Administration of Allogeneic Mesenchymal Stem Cells Seeded in a Collagen Scaffold Augments Wound Healing and Increases Angiogenesis in the Diabetic Rabbit Ulcer
Diabetes published ahead of print February 19 2013 doi:10.2337/db12-1822
About the Clinician Scientist Fellowship Programme (CSFP)
Funded under PRTLI Cycle 4 in 2008 22 medical graduates undertook PhD studies in five academic institutions as MMI Clinician Scientist Fellows. The CSFP is a structured PhD programme which has trained this key group of clinician scientists to graduate with the unique and specialised knowledge essential to fulfil Ireland’s research needs in translational medicine.
Further information on the CSFP can be found at the below link:
The MMI Clinician Scientist Fellowship Programme is funded under the Programme for Research in Third Level Institutions (PRTLI) Cycle 4 and co-funded under the European Regional Development Fund (ERDF).